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KMID : 1098420110190060426
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Korean Journal of Medicinal Crop Science
2011 Volume.19 No. 6 p.426 ~ p.434
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Study on the Anti-inflammatory Effect of Kaempferol and Kaempferol Rhamnosides Isolated from Hibiscus cannabinus L.
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Lee Keun-Ha
Cho Young-Long
Joo Chul-Gue
Joo Yeon-Jeong
Kwon Sun-Sang
Park Chung
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Abstract
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In this study, to evaluate the anti-inflammatory effects of kaempferol and its rhamnosides isolated from Hibiscus cannabinus L. leaves, we investigated UVB-induced inhibitory effects on inflammatory reaction by measuring the cytokine as the prostaglandin (), interleukine-6 (IL-6) and interleukine-8 (IL-8). We investigated the inhibitory effects of kaempferol and its rhamnosides on TARC (thymus and activation-regulated chemokine) and . Kaempferol and -rhamnoisorobin showed inhibition activity of TARC generated to compared to positive control. Kaempferol, -rhamnoisorobin and afzelin Inhibited the release of . Also, only kaempferol significantly inhibited interleukine-6 (IL-6), interleukine-8 (IL-8) among UVB-induced inflammatory cytokine.
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KEYWORD
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Kaempferol, Kaempferol Rhamnosides, Anti-inflammatory Effect, Hibiscus cannabinus L., Cytokine
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